2 The food sources of MUFA in the Mediterranean diet provide many micronutrients and bioactives that also may confer cardioprotective benefits. 1 Both MUFA and PUFA are recommended as the dietary replacement for SFA.
The 2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk recommends a healthy dietary pattern with 5% to 6% of calories from SFA for lowering LDL‐C, a primary target for CVD risk reduction. Furthermore, only the AV diet significantly decreased LDL particle number (LDL‐P, −80.1 nmol/L, P=0.0001), small dense LDL cholesterol (LDL 3+4, −4.1 mg/dL, P=0.04), and the ratio of LDL/HDL (−6.6%, P<0.0001) from baseline.Ī heart healthy diet is recommended for primary and secondary prevention of CVD. Compared with baseline, the reduction in LDL‐C and non‐high‐density lipoprotein (HDL) cholesterol on the AV diet (−13.5 mg/dL, −14.6 mg/dL) was greater ( P<0.05) than the MF (−8.3 mg/dL, −8.7 mg/dL) and LF (−7.4 mg/dL, −4.8 mg/dL) diets. Three cholesterol‐lowering diets (6% to 7% SFA) were fed (5 weeks each): a lower‐fat diet (LF: 24% fat) 2 moderate‐fat diets (34% fat) provided similar foods and were matched for macronutrients and fatty acids: the avocado diet (AV) included one fresh Hass avocado (136 g) per day, and the moderate‐fat diet (MF) mainly used high oleic acid oils to match the fatty acid content of one avocado.
A randomized, crossover, controlled feeding trial was conducted with 45 overweight or obese participants with baseline LDL‐C in the 25th to 90th percentile.
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